
2025-09-09 14:54:16
¿ÆÑ§¼ÒÌá³öAPOE4¾Óɹý³Ìµ¨¹Ì´¼µôµ÷ÇÖº¦ÉÙÍ»½ºÖÊϸ°ûµÄËèÇÊÐγɻúÖÆ
ÈÕÆÚ£º2022-12-13 À´Àú£º±¾Õ¾ ¹©¸å£ºÒ½Ò©ÉúÎï¼¼ÄÜ´¦ ×÷ÕߣºÖÎÀíÔ± ÖÖ±ð£ºÒëÎÄ
ÔØÖ¬ÂѰ×E4£¨Èçϼò³Æ¡°APOE4¡±£©Êǰ¢¶û´Äº£Ä¬²¡ÁªÏµ¹ØÏµÐÔ×îÇ¿µÄÒÅ´«Î£º¦ÒòËØ¡£µ«APOE4±í´ï³Ì¶ÈºÍ¹¦Ð§¶ÔÓÚÈËÄÔµÄÓ°ÏìÉв»Ã÷È·£¬ÕâÏÞ¶¨Á˶ÔÓÚЯ´øAPOE4°¢¶û´Äº£Ä¬²¡Î£º¦ÒòËØ¸ö±ð¿ª·¢°ÐÏòÒ½ÖεıêµÄÄ¿µÄ¡£ÃÀ¹úÂéÊ¡Àí¹¤Ñ§ÔºµÈÑо¿ÍŶӷ¢Ã÷£¬APOE4¾Óɹý³ÌÉÙÍ»½ºÖÊϸ°ûÖе¨¹Ì´¼µôµ÷´Ó¶øÇÖº¦ËèÇÊ¡£¸ÃÑо¿½á¹ûÒÔÌâΪ¡°APOE4impairs myelination via cholesterol dysregulation in oligodendrocytes¡±ÔÚ½üÈÕ·¢±íÓÚ¡¶Nature¡·ÔÓÖ¾ÉÏ¡£ Ñо¿Ö°Ô±¶ÔÓÚAPOE4Я´øÕßÓë·ÇЯ´øÕßÃðÍöºóµÄÈËÄÔ¾ÙÐÐÁ˵¥Ï¸°ûת¼×éѧ²û·¢¡£³É¹û×¢½â£¬APOE4ÏÔÖø×ª±äÁ˵¨¹Ì´¼¾ùºâ¼°ÔËÊäÓйصÄìºÆìµÆºÅͨ·¡£¾Óɹý³Ì¶ÔÓÚÉíºóÈËÄÔ¡¢ÒýÓÕ¶àÄܸÉϸ°ûÑÜÉúµÄϸ°ûµÈ¾ÙÐй¹Ôìѧ¼°Ö¬ÖÊ×é²û·¢·¢Ã÷£¬APOE4Я´øÕßÄêÒ¹ÄÔµÄϸ°ûµ¨¹Ì´¼ÒìÑù³Á»ý£¬ÆäÄêÒ¹ÄÔÖе¨¹Ì´¼¶¨Î»µÄת±äÓëËèÇÊ»¯µÄÏ÷¼õÏàÒ»Ö¡£¶¯ÎïÊÔÑé×¢½â£¬¾Óɹý³ÌÒ©Îï´Ù³Éµ¨¹Ì´¼µÄÔËÊä¿ÉÒÔÔö³¤ÖáÍ»ËèÇÊ»¯£¬¸ÄÉÆÐ¯´øAPOE4СÊóµÄ½øÐÞ¼°Ó°Ïó¹¦Ð§¡£ ¸ÃÑо¿»æÖÆÁËÈËÄÔµ¥Ï¸°ûͼÆ×£¬Õ¹ÏÖÁËAPOE4¶ÔÓÚÈËÀàÄêÒ¹ÄÔÀÏ»¯µÄת¼ӰÏ죬²¢³ÉÁ¢ÁËAPOEËÄ¡¢µ¨¹Ì´¼¡¢ËèÇÊ»¯¼°Ó°ÏóÖ®¼äµÄ¹¦Ð§½ÓÇ¢£¬Îª°¢¶û´Äº£Ä¬²¡ÌṩÁËDZÓÚµÄÒ½ÖÎÒªÁì¡£ ÂÛÎÄÁ´½Ó£ºhttps://www.ÓÀººÕòÔÆ¶¥¼¯ÍÅ-nature.com/articles/s41586-022-05439-w ×¢£º´ËÑо¿½á¹ûÕª×Ô¡¶Nature¡·ÔÓÖ¾£¬ÎÄÕÂÄÚÈݲ»´ú±í±¾ÍøÕ¾²»Ñŵ㼰̬¶È£¬½ö¹©²Î¿¼¡£-ÓÀººÕòÔÆ¶¥¼¯ÍÅ-