ÓÀººÕòÔƶ¥¼¯ÍÅ-¿Æѧ¼Ò·¢ÏÖ¸ÉÑÛÖ¢»á¸Ä±äÑÛ½ÇĤËðÉ˺óµÄÓúºÏ·½Ê½

¿Æѧ¼Ò·¢Ã÷¸ÉÑÛÖ¢»áת±äÑÛ½ÇĤ»ÙÉ˺óµÄÓúºÏ·½Ê½

ÈÕÆÚ£º2023-02-02 À´Àú£º±¾Õ¾ ¹©¸å£º¹ú¼Ê»¥ÖúÓë»ùµØƽ̨´¦ ×÷ÕߣºÖÎÀíÔ± ÖÖ±ð£ºÒëÎÄ

¸ÉÑÛÖ¢£¬ÓÖ±»³ÆΪ½ÇĤ½áĤ¸ÉÔïÖ¢£¬ÊÇÒ»Öָ߷¢µÄÈ«ÊÀ½çÐÔÑÛ±í¼²²¡£¬ÒòΪÆä³£ÒýÆð½Ï×ŵÄÑÛ²¿²»ÊÊÖ¢×´£¬ÑϾþµÄ»¼Õß»á³ÊÏÖ½Ï×ŵÄÄ¿Á¦½µÂä¡£µ±×ÔÈ»ÀáÒºÅÅй²»×㣬²»¿Ë²»¼°¹»Ê¹ÑÛ¾¦Á¬½áÈó»¬Ê±£¬¾Í»á·¢Éú¸ÉÑÛÖ¢¡£»¼ÓиÉÑÛÖ¢µÄÈ˽ÇĤÊÜÉ˵ÄΣº¦¸üÄêÒ¹¡£½üÆÚ£¬»ªÊ¢¶ÙÄêҹѧµÄÑо¿Ö°Ô±·¢Ã÷£¬½ÇĤÉÏƤ¸Éϸ°û£¨LSCs£©ÔÐÓý·¢ÉúµÄÂÑ°×ÖÊ£¬¶àÊÇÒ½Öμ°Ô¤·À´ËÀà»ÙÉ˵Äабê¡£Ñо¿½á¹û·¢±íÓÚ¡¶Proceedings of the National Academy ofSciences of the United States of America¡·ÆÚ¿¯£¬±êÌâΪ¡°Dry eye disease in mice activates adaptivecorneal epithelial regeneration distinct from constitutive renewal inhomeostasis¡±¡£ Ñо¿Ö°Ô±ÀûÓõ¥Ï¸°ûRNA²âÐò¼¼ÄÜ£¬²û·¢Á˼¸ÖÖСÊóÄ£×Ó£¨¿µ½¡¡¢ÐàÂõ¡¢ÌÇÄò²¡¼°¸ÉÑÛÖ¢£©ÖеĽÇĤ±í´ï»ùÒò£¬Ñо¿³É¹ûÏÔʾ£¬ÀáҺȱÉÙÒ×ÖÂʹ½ÇĤ»ÙÉË£¬Í¬Ê±Ñо¿»¹ÓÐÓÀººÕòÔƶ¥¼¯ÍÅ-·¢Ã÷£¬ÓÚ»¼ÓиÉÑÛÖ¢µÄСÊóÖУ¬½ÇĤ¼¤»îÁËSPARC»ùÒòµÄ±í´ï¡£½øÒ»²½µÄ½ÇĤÉÏƤϸ°û»®ºÛÊÔÑé³É¹û×¢½â£¬Ë³Ó¦ÐÔÔÙÉú±ê¼ÇÎïSPARCµÄ±í´ïÒ»Ñù±»ÒýÓÕ£¬ÇÒ¼Ó¿ìÁ˽ÇĤÉÏƤÉË¿ÚµÄÓúºÏ¡£´ËÍ⣬Ñо¿Ö°Ô±»¹ÓÐÌá³öÁËÒ»ÖÖ»ùÔÚÓÚ¿µ½¡¼°¼²²¡Öеıí´ï±£Õæ¶ÈµÄLSC±ê¼ÇÎï·ÖÀàÌåϵ¡£ ¸ÃÑо¿È·¶¨µÄSPARC»ùÒò£¬¶ÔÓÚά³Ö½ÇĤ¿µ½¡ÓÈΪÖ÷Òª£¬Õâ¿ÉÄÜΪ¸ÉÑÛÖ¢¼°½ÇĤ»ÙÉËÌṩDZÓÚµÄÒ½Öΰеã¡£ ÂÛÎÄÁ´½Ó£ºhttps://www.pnas.org/doi/10.1073/pnas.2204134120 ×¢£º´ËÑо¿½á¹ûÕª×Ô¡¶Proceedings of the National Academy of Sciencesof the United States of America¡·ÆÚ¿¯Ô­ÎÄÕ£¬ÎÄÕÂÄÚÈݲ»´ú±í±¾ÍøÕ¾²»Ñŵ㼰̬¶È£¬½ö¹©²Î¿¼¡£-ÓÀººÕòÔƶ¥¼¯ÍÅ-