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Leena B. Mithal, Hannah L. Palac, Ram Yogev, Linda M. Ernst, Karen K. Mestan
Cord Blood Acute Phase Reactants Predict Early Onset Neonatal Sepsis in Preterm Infants
www.plosone.org
www.plosone.org
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1.4684 0 Td
(Prentice)Tj
3.5376 0 Td
(NICU)Tj
-34.9396 -1.3039 Td
(Cord)Tj
2.2903 0 Td
(Blood)Tj
2.5852 0 Td
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2.7326 0 Td
(a)Tj
0.652 0 Td
(longitudinal)Tj
5.1023 0 Td
(birth)Tj
2.194 0 Td
(cohort)Tj
2.8516 0 Td
(established)Tj
4.5978 0 Td
(in)Tj
1.0375 0 Td
(2008)Tj
2.1203 0 Td
(at)Tj
0.9524 0 Td
(Prentice)Tj
3.5376 0 Td
(Women's)Tj
4.0592 0 Td
(Hospi-)Tj
-34.7128 -1.2982 Td
(tal)Tj
1.1962 0 Td
(\(Chicago,)Tj
4.0762 0 Td
(IL\).)Tj
1.661 0 Td
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4.8019 0 Td
(was)Tj
1.6951 0 Td
(dependent)Tj
4.4617 0 Td
(on)Tj
1.2756 0 Td
(parental)Tj
3.4923 0 Td
(consent)Tj
3.3278 0 Td
(and)Tj
1.7348 0 Td
(availability)Tj
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(of)Tj
1.0148 0 Td
(cord)Tj
-33.2671 -1.2983 Td
(blood.)Tj
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1.2019 0 Td
(the)Tj
1.4683 0 Td
(time)Tj
2.0296 0 Td
(of)Tj
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(study,)Tj
2.6192 0 Td
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3.8778 0 Td
(pertinent)Tj
3.9174 0 Td
(clinical)Tj
3.0728 0 Td
(data)Tj
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(was)Tj
1.6951 0 Td
(available)Tj
3.668 0 Td
(for)Tj
1.389 0 Td
(1,100)Tj
2.347 0 Td
(enrollees)Tj
/F11 1 Tf
0 Tc
-32.9553 -1.2983 Td
(<)Tj
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-0.004 Tc
(37)Tj
1.9388 0 Td
(weeks)Tj
2.6136 0 Td
(gestational)Tj
4.5014 0 Td
(age)Tj
1.542 0 Td
(born)Tj
2.1543 0 Td
(between)Tj
3.5263 0 Td
(2008)Tj
2.126 0 Td
(and)Tj
1.7291 0 Td
(2014.)Tj
2.347 0 Td
(Umbilical)Tj
4.167 0 Td
(venous)Tj
3.0443 0 Td
(cord)Tj
2.0466 0 Td
(blood)Tj
2.5172 0 Td
(was)Tj
-34.2536 -1.3039 Td
(collected)Tj
3.736 0 Td
(at)Tj
0.9524 0 Td
(delivery)Tj
3.3902 0 Td
(into)Tj
1.8425 0 Td
(EDTA)Tj
2.8177 0 Td
(tubes)Tj
2.3414 0 Td
(and)Tj
1.7291 0 Td
(spun)Tj
2.177 0 Td
(at)Tj
0.9524 0 Td
(3,000rpm)Tj
4.0535 0 Td
(for)Tj
1.389 0 Td
(10)Tj
1.1679 0 Td
(minutes)Tj
3.4639 0 Td
(in)Tj
1.0375 0 Td
(a)Tj
0.6519 0 Td
(refrigerated)Tj
-31.7024 -1.2982 Td
(tabletop)Tj
3.4525 0 Td
(centrifuge)Tj
4.252 0 Td
(to)Tj
1.0261 0 Td
(separate)Tj
3.4866 0 Td
(plasma,)Tj
3.2541 0 Td
(which)Tj
2.6533 0 Td
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1.6951 0 Td
(stored)Tj
2.7099 0 Td
(at)Tj
0.9524 0 Td
(-80C)Tj
2.5795 0 Td
(until)Tj
2.109 0 Td
(assay.)Tj
2.4888 0 Td
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-30.6593 -1.2983 Td
(clinical)Tj
3.0727 0 Td
(data)Tj
1.9162 0 Td
(of)Tj
1.0148 0 Td
(maternal)Tj
3.7984 0 Td
(and)Tj
1.7291 0 Td
(infant)Tj
2.6022 0 Td
(variables)Tj
3.719 0 Td
(including)Tj
4.0422 0 Td
(demographic)Tj
5.5049 0 Td
(information,)Tj
5.3007 0 Td
(maternal)Tj
-32.7002 -1.3039 Td
(risk)Tj
1.7121 0 Td
(factors,)Tj
3.1294 0 Td
(perinatal)Tj
3.7644 0 Td
(complications)Tj
5.8393 0 Td
(leading)Tj
3.1294 0 Td
(to)Tj
1.0262 0 Td
(preterm)Tj
3.4469 0 Td
(delivery,)Tj
3.6113 0 Td
(laboratory)Tj
4.354 0 Td
(values,)Tj
2.8913 0 Td
(culture)Tj
-32.9043 -1.2983 Td
(results,)Tj
3.033 0 Td
(and)Tj
1.7291 0 Td
(antibiotics)Tj
4.3994 0 Td
(administered)Tj
5.4878 0 Td
(were)Tj
2.126 0 Td
(recorded)Tj
3.7927 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4683 0 Td
(study)Tj
2.3924 0 Td
(database.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 443.3385 cm
BT
/F0 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Patient)Tj
3.2976 0 Td
(selection)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 426.3874 cm
BT
/F7 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Based)Tj
2.5454 0 Td
(on)Tj
1.2756 0 Td
(culture)Tj
3.0387 0 Td
(results,)Tj
3.0331 0 Td
(antibiotic)Tj
4.0365 0 Td
(treatment)Tj
4.1386 0 Td
(and)Tj
1.7291 0 Td
(laboratory)Tj
4.3483 0 Td
(data,)Tj
2.143 0 Td
(1,100)Tj
2.3471 0 Td
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3.3675 0 Td
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(classi-)Tj
-34.1232 -1.3039 Td
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1.7234 0 Td
(by)Tj
1.1849 0 Td
(the)Tj
1.4683 0 Td
(following)Tj
3.9798 0 Td
(sepsis)Tj
2.5115 0 Td
(categories:)Tj
4.4164 0 Td
(confirmed)Tj
4.3993 0 Td
(EOS)Tj
2.0126 0 Td
(\(cEOS\),)Tj
3.3392 0 Td
(presumed)Tj
4.1896 0 Td
(EOS)Tj
2.0125 0 Td
(\(PS\),)Tj
2.16 0 Td
(late)Tj
1.6214 0 Td
(onset)Tj
-35.0189 -1.2982 Td
(sepsis)Tj
2.5114 0 Td
(\(LOS\),)Tj
2.8857 0 Td
(and)Tj
1.7291 0 Td
(controls)Tj
3.4809 0 Td
(according)Tj
4.1896 0 Td
(to)Tj
1.0261 0 Td
(pre-determined)Tj
6.514 0 Td
(criteria)Tj
3.0728 0 Td
(based)Tj
2.4774 0 Td
(upon)Tj
2.3187 0 Td
(National)Tj
3.6907 0 Td
(Institute)Tj
-33.8964 -1.2983 Td
(of)Tj
1.0147 0 Td
(Child)Tj
2.4492 0 Td
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2.9196 0 Td
(and)Tj
1.7292 0 Td
(Human)Tj
3.3165 0 Td
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5.6182 0 Td
(\(NICHD\))Tj
4.1442 0 Td
(definitions)Tj
4.5241 0 Td
(for)Tj
1.389 0 Td
(premature)Tj
4.405 0 Td
(infants)Tj
2.965 0 Td
([)Tj
0.83 0.64 0.02 0 k
(29)Tj
0 g
(])Tj
-34.4747 -1.3039 Td
(\()Tj
0.83 0.64 0.02 0 k
(Fig)Tj
1.8198 0 Td
(1)Tj
0 g
(\).)Tj
1.2586 0 Td
(Infants)Tj
3.0387 0 Td
(were)Tj
2.1259 0 Td
(considered)Tj
4.5978 0 Td
(to)Tj
1.0261 0 Td
(have)Tj
2.058 0 Td
(cEOS)Tj
2.4378 0 Td
(if)Tj
0.7767 0 Td
(a)Tj
0.6519 0 Td
(positive)Tj
3.3165 0 Td
(blood)Tj
2.5115 0 Td
(culture)Tj
3.0387 0 Td
(was)Tj
1.7008 0 Td
(present)Tj
3.1635 0 Td
(in)Tj
1.0374 0 Td
(the)Tj
-34.5597 -1.2983 Td
(first)Tj
1.8028 0 Td
(72)Tj
1.1735 0 Td
(hours)Tj
2.5115 0 Td
(of)Tj
1.0148 0 Td
(life)Tj
1.4456 0 Td
(\(HOL\))Tj
2.9537 0 Td
(with)Tj
1.9956 0 Td
(a)Tj
0.6576 0 Td
(single)Tj
2.5285 0 Td
(bacterial)Tj
3.6284 0 Td
(pathogen)Tj
3.9401 0 Td
(and)Tj
1.7291 0 Td
(they)Tj
1.9276 0 Td
(received)Tj
3.5319 0 Td
(an)Tj
1.2019 0 Td
(antibiotic)Tj
-32.0426 -1.2982 Td
(course)Tj
2.8346 0 Td
(for)Tj
/F12 1 Tf
0 Tc
1.3833 0 Td
()Tj
/F7 1 Tf
-0.004 Tc
(5)Tj
1.4683 0 Td
(days.)Tj
2.2224 0 Td
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1.3379 0 Td
(maintain)Tj
3.8381 0 Td
(a)Tj
0.652 0 Td
(stringent)Tj
3.804 0 Td
(definition)Tj
4.1613 0 Td
(of)Tj
1.0148 0 Td
(cEOS)Tj
2.4377 0 Td
(for)Tj
1.3833 0 Td
(this)Tj
1.6781 0 Td
(study,)Tj
2.6136 0 Td
(patients)Tj
3.3675 0 Td
(with)Tj
-34.1969 -1.304 Td
(questionable)Tj
5.2667 0 Td
(true)Tj
1.8425 0 Td
(EOS)Tj
2.0126 0 Td
(pathogens,)Tj
4.5297 0 Td
(such)Tj
2.058 0 Td
(as)Tj
/F13 1 Tf
1.0148 0 Td
[()-2()11()-20()-13()6()20()4()6( )-4(\n)11()2()-9()12()12(\r)]TJ
/F7 1 Tf
(,)Tj
7.2056 0 Td
(those)Tj
2.3357 0 Td
(with)Tj
1.9956 0 Td
(positive)Tj
3.3165 0 Td
(respiratory)Tj
-31.5777 -1.2982 Td
(cultures)Tj
3.3958 0 Td
(only,)Tj
2.2054 0 Td
(and)Tj
1.7291 0 Td
(those)Tj
2.3357 0 Td
(with)Tj
2.0013 0 Td
(viral)Tj
1.9899 0 Td
(or)Tj
1.0998 0 Td
(fungal)Tj
2.7269 0 Td
(sepsis)Tj
2.5115 0 Td
(were)Tj
2.126 0 Td
(not)Tj
1.5704 0 Td
(classified)Tj
3.821 0 Td
(as)Tj
1.0148 0 Td
(confirmed)Tj
4.3937 0 Td
(EOS)Tj
2.0126 0 Td
(cases.)Tj
-34.9339 -1.2983 Td
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3.033 0 Td
(with)Tj
1.9899 0 Td
(PS)Tj
1.2472 0 Td
(were)Tj
2.1203 0 Td
(patients)Tj
3.3619 0 Td
(with)Tj
1.9899 0 Td
(no)Tj
1.2699 0 Td
(positive)Tj
3.3109 0 Td
(culture,)Tj
3.2541 0 Td
(but)Tj
1.5477 0 Td
(with)Tj
/F12 1 Tf
0 Tc
1.9956 0 Td
()Tj
/F7 1 Tf
-0.004 Tc
(2)Tj
1.457 0 Td
(abnormal)Tj
4.0819 0 Td
(laboratory)Tj
4.3483 0 Td
(results)Tj
-35.0076 -1.3039 Td
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2.2053 0 Td
(peripheral)Tj
4.32 0 Td
(blood)Tj
2.5114 0 Td
(indicative)Tj
4.1329 0 Td
(of)Tj
1.0148 0 Td
(sepsis)Tj
2.5115 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4683 0 Td
(first)Tj
1.8028 0 Td
(72)Tj
1.1736 0 Td
(HOL)Tj
2.2733 0 Td
(and)Tj
1.7292 0 Td
(who)Tj
1.9389 0 Td
(received)Tj
3.5376 0 Td
(antibiotic)Tj
-31.6571 -1.2983 Td
(treatment)Tj
4.1328 0 Td
(for)Tj
/F12 1 Tf
0 Tc
1.389 0 Td
()Tj
/F7 1 Tf
-0.004 Tc
(5)Tj
1.4683 0 Td
(days)Tj
1.9956 0 Td
(at)Tj
0.9525 0 Td
(birth)Tj
2.1883 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(Fig)Tj
1.8198 0 Td
(1)Tj
0 g
(\).)Tj
1.2643 0 Td
(Abnormal)Tj
4.3369 0 Td
(postnatal)Tj
3.8665 0 Td
(laboratory)Tj
4.3483 0 Td
(results)Tj
2.8119 0 Td
(were:)Tj
2.3471 0 Td
(CRP)Tj
/F12 1 Tf
0 Tc
-32.9213 -1.2982 Td
()Tj
/F7 1 Tf
-0.004 Tc
(1mg/dL)Tj
4.1442 0 Td
([)Tj
0.83 0.64 0.02 0 k
(7)Tj
0 g
(],)Tj
1.6044 0 Td
(absolute)Tj
3.5206 0 Td
(neutrophil)Tj
4.456 0 Td
(count)Tj
2.5285 0 Td
(outside)Tj
3.1294 0 Td
(normal)Tj
3.1465 0 Td
(range)Tj
2.4661 0 Td
(based)Tj
2.4718 0 Td
(on)Tj
1.2756 0 Td
(published)Tj
4.1215 0 Td
(guidelines)Tj
-32.8646 -1.2983 Td
(according)Tj
4.1839 0 Td
(to)Tj
1.0261 0 Td
(gestational)Tj
4.5071 0 Td
(age)Tj
1.542 0 Td
([)Tj
0.83 0.64 0.02 0 k
(30)Tj
0 g
(],)Tj
2.0749 0 Td
(and)Tj
1.7292 0 Td
(elevated)Tj
3.4525 0 Td
(immature-to-total)Tj
7.4721 0 Td
(neutrophil)Tj
4.4561 0 Td
(ratio)Tj
/F11 1 Tf
0 Tc
2.0976 0 Td
(>)Tj
/F7 1 Tf
-0.004 Tc
(0.2)Tj
2.1656 0 Td
([)Tj
0.83 0.64 0.02 0 k
(31)Tj
0 g
(].)Tj
-34.7071 -1.3039 Td
(Control)Tj
3.3618 0 Td
(patients)Tj
3.3676 0 Td
(had)Tj
1.7064 0 Td
(no)Tj
1.2756 0 Td
(positive)Tj
3.3165 0 Td
(culture)Tj
3.0387 0 Td
(throughout)Tj
4.7792 0 Td
(hospitalization)Tj
6.1115 0 Td
(and)Tj
1.7348 0 Td
(were)Tj
2.1203 0 Td
(never)Tj
2.4434 0 Td
(treated)Tj
-33.2558 -1.2983 Td
(with)Tj
/F11 1 Tf
0 Tc
1.9955 0 Td
(>)Tj
/F7 1 Tf
-0.004 Tc
(4)Tj
1.4684 0 Td
(days)Tj
1.9955 0 Td
(of)Tj
1.0148 0 Td
(antibiotics)Tj
4.3994 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(Table)Tj
2.7836 0 Td
(1)Tj
0 g
(\).)Tj
1.2586 0 Td
(The)Tj
1.7858 0 Td
(majority)Tj
3.6283 0 Td
(of)Tj
1.0148 0 Td
(control)Tj
3.1181 0 Td
(patients)Tj
3.3675 0 Td
(\(24/30\))Tj
3.1351 0 Td
(received)Tj
3.532 0 Td
(23)Tj
-34.4974 -1.2982 Td
(days)Tj
1.9955 0 Td
(of)Tj
1.0148 0 Td
(antibiotics)Tj
4.3994 0 Td
(as)Tj
1.0148 0 Td
(rule-out)Tj
4.2576 0 Td
(of)Tj
1.0148 0 Td
(sepsis)Tj
2.5115 0 Td
(until)Tj
2.1089 0 Td
(blood)Tj
2.5115 0 Td
(culture)Tj
3.0387 0 Td
(was)Tj
1.7008 0 Td
(negative.)Tj
3.7587 0 Td
(PS)Tj
1.2529 0 Td
(and)Tj
1.7348 0 Td
(control)Tj
-32.3147 -1.304 Td
(patients)Tj
3.3675 0 Td
(were)Tj
2.1203 0 Td
(frequency)Tj
4.1896 0 Td
(matched)Tj
3.6736 0 Td
(based)Tj
2.4718 0 Td
(on)Tj
1.2756 0 Td
(gestational)Tj
4.5071 0 Td
(age)Tj
1.542 0 Td
(and)Tj
1.7291 0 Td
(birth)Tj
2.1884 0 Td
(weight)Tj
2.8856 0 Td
(ranges)Tj
2.829 0 Td
(in)Tj
1.0318 0 Td
(a)Tj
0.6576 0 Td
(2:1)Tj
-34.469 -1.2982 Td
(ratio)Tj
2.0976 0 Td
(to)Tj
1.0261 0 Td
(cEOS)Tj
2.4321 0 Td
(cases)Tj
2.2224 0 Td
(by)Tj
1.1848 0 Td
(gestational)Tj
4.5014 0 Td
(age)Tj
1.5421 0 Td
(\(+/-)Tj
1.8198 0 Td
(3)Tj
0.6973 0 Td
(weeks\))Tj
2.948 0 Td
(and)Tj
1.7292 0 Td
(birth)Tj
2.194 0 Td
(weight)Tj
2.8856 0 Td
(\(+/-)Tj
1.8198 0 Td
(400)Tj
1.6441 0 Td
(grams\).)Tj
3.2372 0 Td
(In)Tj
-33.9815 -1.2983 Td
(situations)Tj
4.0875 0 Td
(where)Tj
2.6532 0 Td
(more)Tj
2.3414 0 Td
(than)Tj
2.0296 0 Td
(one)Tj
1.6951 0 Td
(PS)Tj
1.2586 0 Td
(or)Tj
1.0941 0 Td
(control)Tj
3.1238 0 Td
(patient)Tj
3.0047 0 Td
(matched)Tj
3.6737 0 Td
(to)Tj
1.0261 0 Td
(the)Tj
1.474 0 Td
(case,)Tj
2.0863 0 Td
(patients)Tj
3.3675 0 Td
(were)Tj
2.1203 0 Td
(ran-)Tj
-35.0359 -1.3039 Td
(domly)Tj
2.7722 0 Td
(selected,)Tj
3.5716 0 Td
(masked)Tj
3.2825 0 Td
(to)Tj
1.0262 0 Td
(all)Tj
1.1508 0 Td
(clinical)Tj
3.0728 0 Td
(information,)Tj
5.3007 0 Td
(including)Tj
4.0422 0 Td
(laboratory)Tj
4.354 0 Td
(values)Tj
2.6645 0 Td
(and)Tj
1.7292 0 Td
(placental)Tj
-32.9667 -1.2983 Td
(histology.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 125.9716 cm
BT
/F0 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Cord)Tj
2.3622 0 Td
(blood)Tj
2.6268 0 Td
(biomarkers)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 109.0204 cm
BT
/F7 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Nine)Tj
2.194 0 Td
(APR)Tj
2.0862 0 Td
(proteins)Tj
3.515 0 Td
(were)Tj
2.1203 0 Td
(measured)Tj
4.1102 0 Td
(in)Tj
1.0318 0 Td
(cord)Tj
2.0523 0 Td
(blood:)Tj
2.7382 0 Td
(PCT,)Tj
2.2791 0 Td
(CRP,)Tj
2.2903 0 Td
(haptoglobin)Tj
5.0457 0 Td
(\(Hp\),)Tj
2.4094 0 Td
(ferritin,)Tj
-31.8725 -1.3039 Td
(fibrinogen,)Tj
4.6374 0 Td
(tissue)Tj
2.4605 0 Td
(plasminogen)Tj
5.3574 0 Td
(activator,)Tj
3.9345 0 Td
(serum)Tj
2.7212 0 Td
(amyloid)Tj
3.4753 0 Td
(A)Tj
0.907 0 Td
(\(SAA\),)Tj
2.9651 0 Td
(serum)Tj
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